Endocrine Abstracts

Case history: We report a 56-year-old man who was referred to the Endocrinology Clinic with hypokalaemic hypertension. He had a history of bladder cancer 9-years previously, treated with surgery, chemotherapy and BCG therapy. At referral, he was taking Amlodipine 10 mg and Doxazosin 8 mg twice daily with average home blood pressure readings of 160/90 mmHg.Investigations: Aldosterone to renin ratio (ARR), taken on Doxazosin with potassium 3.6 mmol/l was 3...

A 38-year-old lady, who was 9 months post-partum, presented in 2008 with hirsutism, acne and abdominal discomfort. She was virilised and had an easily palpable right upper quadrant mass. Biochemistry revealed mild hypokalaemia (K 3.3 mmol/l), low albumin and gross elevation of serum androgens (androstenedione 93.9 nmol/l, DHAS 37.7 μmol/l and testosterone 13.7 nmol/l). UFC was 380 nmol/24 h but following 1 mg dexamethasone, cortisol suppressed fully. Urine steroi...

A 29-year-old lady presented with features of Cushing’s syndrome in October 2014. Investigations confirmed ACTH–dependent Cushing’s syndrome. An MRI scan showed a 4.5 mm right-sided pituitary lesion and subsequent inferior petrosal sinus sampling confirmed a central source of ACTH hypersecretion. She underwent trans-sphenoidal pituitary surgery in January 2015. Histology confirmed a corticotroph adenoma with a Ki-67 proliferation index of 1%. However, a mean cor...